Last year at Pageflakes, when we were getting millions of hits per day, we were having query timeout due to lock timeout and Transaction Deadlock errors. These locks were produced from aspnet_Users and aspnet_Membership tables. Since both of these tables are very high read (almost every request causes a read on these tables) and high write (every anonymous visit creates a row on aspnet_Users), there were just way too many locks created on these tables per second. SQL Counters showed thousands of locks per second being created. Moreover, we had queries that would select thousands of rows from these tables frequently and thus produced more locks for longer period, forcing other queries to timeout and thus throw errors on the website.
If you have read my last blog post, you know why such locks happen. Basically every table when it grows up to hold millions of records and becomes popular goes through this trouble. It’s just a part of scalability problem that is common to database. But we rarely take prevention about it in our early design.